General Information

  • ID:  hor003008
  • Uniprot ID:  P40753
  • Protein name:  Brain natriuretic peptide
  • Gene name:  Nppb
  • Organism:  Mus musculus (Mouse)
  • Family:  Natriuretic peptide family
  • Source:  animal
  • Expression:  [Brain natriuretic peptide 45]: Expressed abundantly in the ventricle, and in a lesser extent in the atrium (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005515 protein binding; GO:0051427 hormone receptor binding
  • GO BP:  GO:0000165 MAPK cascade; GO:0001935 endothelial cell proliferation; GO:0003008 system process; GO:0003085 negative regulation of systemic arterial blood pressure; GO:0006182 cGMP biosynthetic process; GO:0006457 protein folding; GO:0006950 response to stress; GO:0007168 receptor guanylyl cyclase signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0010753 positive regulation of cGMP-mediated signaling; GO:0014898 cardiac muscle hypertrophy in response to stress; GO:0019934 cGMP-mediated signaling; GO:0030308 negative regulation of cell growth; GO:0031640 killing of cells of another organism; GO:0031667 response to nutrient levels; GO:0035810 positive regulation of urine volume; GO:0048662 negative regulation of smooth muscle cell proliferation; GO:0048872 homeostasis of number of cells; GO:0060976 coronary vasculature development; GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide; GO:0070482 response to oxygen levels; GO:0097746 blood vessel diameter maintenance; GO:1903816 positive regulation of collecting lymphatic vessel constriction; GO:1904055 negative regulation of cholangiocyte proliferation
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm; GO:0032991 protein-containing complex; GO:0048471 perinuclear region of cytoplasm

Sequence Information

  • Sequence:  SQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL
  • Length:  45(77-121)
  • Propeptide:  MDLLKVLSQMILFLLFLYLSPLGGHSYPLGSPSQSPEQFKMQKLLELIREKSEEMAQRQLLKDQGLTKEHPKRVLRSQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL
  • Signal peptide:  MDLLKVLSQMILFLLFLYLSPLGGHS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Npr1, Npr3
  • Target Unid:  P18293, P70180
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  23-39
  • Structure ID:  AF-Q9M2Y0-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9M2Y0-F1.pdbhor003008_AF2.pdbhor003008_ESM.pdb

Physical Information

Mass: 570668 Formula: C209H356N70O63S2
Absent amino acids: EMWY Common amino acids: S
pI: 11.58 Basic residues: 9
Polar residues: 17 Hydrophobic residues: 13
Hydrophobicity: -35.78 Boman Index: -9616
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 90.89
Instability Index: 5070 Extinction Coefficient cystines: 125
Absorbance 280nm: 2.84

Literature

  • PubMed ID:  NA
  • Title:  NA